Article

Increased excitability of dentate gyrus mossy cells occurs early in life in the Tg2576 model of Alzheimer’s disease

2024-02-12

Abstract excerpt

<h4>ABSTRACT</h4> <h4>INTRODUCTION</h4> Hyperexcitability in Alzheimer’s disease (AD) emerge early and contribute to disease progression. The dentate gyrus (DG) is implicated in hyperexcitability in AD. We hypothesized that mossy cells (MCs), regulators of DG excitability, contribute to early hyperexcitability in AD. Indeed, MCs generate hyperexcitability in epilepsy. <h4>METHODS</h4> Using the Tg2576 model and...

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Literature Corpus work: 07901c85-316b-5cee-9ae5-e92c6bd6953c
DOI: 10.1101/2024.02.09.579729

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