Article

NATO3 protects dopaminergic neurons in mouse <i>in vivo</i> and human <i>in vitro</i> Parkinson’s disease models

2025-10-10

Abstract excerpt

Parkinson’s disease (PD) is a devastating neurodegenerative disorder primarily characterized by the progressive and unstoppable loss of dopaminergic (DA) neurons in the substantia nigra. We previously identified NATO3 (FERD3L), a conserved developmental transcription factor, as essential for maintaining DA neuron function during aging. Here, we show that AAV-mediated Nato3 gene transfer into the mouse substantia...

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Literature Corpus work: 01763956-f05c-5ef5-8671-e5c9249c269c
DOI: 10.1101/2025.10.10.681573

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