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Parkinson’s disease-related Miro1 mutation induces mitochondrial dysfunction and loss of dopaminergic neurons in vitro and in vivo

2023-12-19

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The complex and heterogeneous nature of Parkinson’s disease (PD) is still not fully understood, however, increasing evidence supports mitochondrial impairments as a major driver of neurodegeneration in PD. Recently, the regulator of mitochondrial homeostasis Miro1 has been linked genetically and pathophysiologically to PD. Using 2D and 3D patient-based induced pluripotent stem cells models, including an isogenic c...

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Literature Corpus work: 5189d212-0582-5a29-a1ea-0839eaab7817
DOI: 10.1101/2023.12.19.571978

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Parkinson’s disease-related Miro1 mutation induces mitochondrial dysfunction and loss of dopaminergic neurons <i>in vitro</i> and <i>in vivo</i>

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