Article

Neural cell state modulation by <i>PARK2</i> and dopaminergic neuroprotection by small molecule Parkin agonism

2026-04-04

Abstract excerpt

Parkin, an E3 ubiquitin ligase encoded by PARK2 , plays a key role in both hereditary and sporadic Parkinson’s disease (PD), yet there are no therapies currently available that can target this important pathway. Here, we show that Parkin is critical for successful neuronal differentiation and survival, and we develop small-molecule Parkin agonists that can protect dopaminergic neurons. Upon differentiation of neu...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 15d52551-eadb-5eec-bf61-9c089372001c
DOI: 10.64898/2026.04.01.715918

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Neural cell state modulation by <i>PARK2</i> and dopaminergic neuroprotection by small molecule Parkin agonismDOI 10.64898/2026.04.01.715918Read

Pathologic and therapeutic implications for the cell biology of parkin.Semantic proximity Read

Parkin controls dopamine utilization in human midbrain dopaminergic neurons derived from induced pluripotent stem cells.Semantic proximity Read

Oxidative switch drives mitophagy defects in dopaminergic <i>parkin</i> mutant patient neuronsSemantic proximity Read

iPS models of Parkin and PINK1.Semantic proximity Read

Therapeutic potential of Parkin and its regulation in Parkinson's disease.Semantic proximity Read

Modeling Cell-Cell Interactions in Parkinson’s Disease Using Human Stem Cell-Based ModelsSemantic proximity Read

Small Molecules Greatly Improve Conversion of Human-Induced Pluripotent Stem Cells to the Neuronal LineageSemantic proximity Read

Highly enriched hiPSC-derived midbrain dopaminergic neurons robustly models Parkinson’s diseaseSemantic proximity Read

The cell biology of Parkinson’s diseaseSemantic proximity Read

Mitochondrial dysfunction associated with increased oxidative stress and α-synuclein accumulation in PARK2 iPSC-derived neurons and postmortem brain tissueSemantic proximity Read

Lysosomal perturbations in human dopaminergic neurons derived from induced pluripotent stem cells with PARK2 mutationSemantic proximity Read

Derivation, Characterization, and Neural Differentiation of Integration-Free Induced Pluripotent Stem Cell Lines from Parkinson's Disease Patients Carrying SNCA, LRRK2, PARK2, and GBA Mutations.Semantic proximity Read