Article

Age-related inflammatory changes and perineuronal net dynamics: implications for neurodegenerative disorders

2025-09-15

Abstract excerpt

<h4>Background</h4> Healthy aging alone can lead to cognitive decline, decreased brain size, protein aggregation, accumulation of senescent cells and neuroinflammation. Furthermore, age is the primary risk factor for several neurodegenerative disorders such as Parkinson’s and Alzheimer’s disease. Age-related neuroinflammation, as known as inflammaging, is thought to restrict brain plasticity. Perineuronal nets (P...

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Literature Corpus work: 015ee879-8dc1-5819-9f55-2967ccc83331
DOI: 10.1101/2025.09.10.675190

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