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Article

Microglia facilitate loss of perineuronal nets in the Alzheimer's disease brain.

EBioMedicine - 1 Aug 2020

Crapser Joshua D, Spangenberg Elizabeth E, Barahona Rocio A, Arreola Miguel A, Hohsfield Lindsay A, Green Kim N

Abstract excerpt

BACKGROUND: Microglia, the brain's principal immune cell, are increasingly implicated in Alzheimer's disease (AD), but the molecular interfaces through which these cells contribute to amyloid beta (Aβ)-related neurodegeneration are unclear. We recently identified microglial contributions to the homeostatic and disease-associated modulation of perineuronal nets (PNNs), extracellular matrix structures that enwrap...

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Identifiers

PMID: 32745992
DOI: 10.1016/j.ebiom.2020.102919
PMCID: PMC7399129

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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