Article

Enriched environment requires remodeling of hippocampal perineuronal nets to trigger memory improvement in Alzheimer’s mouse model

2024-10-24

Abstract excerpt

Alzheimer’s disease (AD) is a major neurodegenerative disorder influenced by both genetic and environmental factors. Engaging in mentally stimulating activities is believed to reduce cognitive decline by establishing a cognitive reserve, though the underlying neurobiological mechanisms remain elusive. In this study, we explore the role of parvalbumin-expressing inhibitory neurons (PV) and their associated perineur...

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Literature Corpus work: f75200e7-021e-54a4-b295-d3d3e2883b2b
DOI: 10.1101/2024.10.24.619979

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