Article

Regulation of Store-Operated Ca <sup>2+</sup> Entry by IP <sub>3</sub> Receptors Independent of Their Ability to Release Ca <sup>2+</sup>

2022-04-13

Abstract excerpt

<h4>ABSTRACT</h4> Loss of endoplasmic reticular (ER) Ca 2+ activates store-operated Ca 2+ entry (SOCE) by causing the ER localized Ca 2+ sensor STIM to unfurl domains that activate Orai channels in the plasma membrane at membrane contact sites (MCS). Here we demonstrate a novel mechanism by which the inositol 1,4,5 trisphosphate receptor (IP 3 R), an ER-localized IP 3 -gated Ca 2+ channel, regulates neurona...

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Literature Corpus work: 015d7900-12cd-5178-a555-28b9b8d7b47e
DOI: 10.1101/2022.04.12.488111

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Regulation of Store-Operated Ca <sup>2+</sup> Entry by IP <sub>3</sub> Receptors Independent of Their Ability to Release Ca <sup>2+</sup>DOI 10.1101/2022.04.12.488111Read

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