Article
STIM is a Ca2+ sensor essential for Ca2+-store-depletion-triggered Ca2+ influx.
Current biology : CB - 12 Jul 2005
Liou Jen, Kim Man Lyang, Heo Won Do, Jones Joshua T, Myers Jason W, Ferrell James E, Meyer Tobias
Abstract excerpt
Ca(2+) signaling in nonexcitable cells is typically initiated by receptor-triggered production of inositol-1,4,5-trisphosphate and the release of Ca(2+) from intracellular stores. An elusive signaling process senses the Ca(2+) store depletion and triggers the opening of plasma membrane Ca(2+) channels. The resulting sustained Ca(2+) signals are required for many physiological responses, such as T cell activation...
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