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Article

Ca2+-store-dependent and -independent reversal of Stim1 localization and function.

Journal of cell science - 15 Mar 2008

Smyth Jeremy T, Dehaven Wayne I, Bird Gary S, Putney James W

Abstract excerpt

Stim1 responds to depletion of ER Ca2+ stores by rearranging from tubular structures throughout the ER into punctate structures near the plasma membrane, where it activates Orai store-operated Ca2+ entry (SOCE) channels. However, the mechanism and structural determinants of the localization and reversal of Stim1 puncta formation are poorly understood. Using HEK293 cells expressing Stim1 tagged with enhanced...

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Identifiers

PMID: 18285445
DOI: 10.1242/jcs.023903
PMCID: PMC2587154

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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