Location and function of STIM1 in the activation of Ca2+ entry signals.

Abstract excerpt

Store-operated channels (SOCs) mediate Ca(2+) entry signals in response to endoplasmic reticulum (ER) Ca(2+) depletion in most cells. STIM1 senses decreased ER luminal Ca(2+) through its EF-hand Ca(2+)-binding motif and aggregates in near-plasma membrane (PM) ER junctions to activate PM Orai1, the functional SOC. STIM1 is also present in the PM, although its role there is unknown. STIM1-mediated coupling was...

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• Antibodies, Monoclonal
• Biotinylation
• Calcium
• Fluorescence Resonance Energy Transfer
• Models, Chemical