Article

<i>In vivo</i> xenogenic reconstitution of human alveolar epithelial architecture and function

2026-01-12

Abstract excerpt

An urgent need exists for lung models that accurately replicate human physiological profiles. We developed a chimeric mouse model enabling targeted ablation of alveolar type 2 (AT2) cells and lung macrophages, creating niches for endoscopically transplanted human induced pluripotent stem cell (hiPSC)-derived lung progenitors (hLPs). These engrafted cells were retained for 24 weeks, demonstrating self-renewal and d...

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Literature Corpus work: 015aca42-c358-58d5-8c4c-980e5a99b12f
DOI: 10.64898/2026.01.11.698914

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