Article

A novel human fetal lung-derived alveolar organoid model reveals mechanisms of surfactant protein C maturation relevant to interstitial lung disease

2023-08-30

Abstract excerpt

Alveolar type 2 (AT2) cells maintain lung health by acting as stem cells and producing pulmonary surfactant 1–3 . AT2 dysfunction underlies many lung diseases including interstitial lung disease (ILD), in which some inherited forms result from mislocalisation of surfactant protein C (SFTPC) variants 4,5 . Disease modelling and dissection of mechanisms remains challenging due to complexities in deriving and maint...

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Literature Corpus work: 3fcfb694-66f8-536a-b051-52fefaffa0b9
DOI: 10.1101/2023.08.30.555522

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