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Durable alveolar engraftment of PSC-derived lung epithelial cells into immunocompetent mice

24 Aug 2023

Abstract excerpt

Durable reconstitution of the distal lung epithelium with pluripotent stem cell (PSC) derivatives, if realized, would represent a promising therapy for diseases that result from alveolar damage. Here, we differentiate murine PSCs into self-renewing lung epithelial progenitors able to engraft into the injured distal lung epithelium of immunocompetent, syngeneic mouse recipients. After transplantation, these...

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PMID: 37625412
DOI: 10.1016/j.stem.2023.07.016

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