Article

Directed Differentiation of Human Pluripotent Stem Cells to Functionally Mature Lung Alveolar Cells.

2025-11-12

Abstract excerpt

<title>Abstract</title> <p>Gas exchange occurs in the alveolar sacs, composed of alveolar type 1 (AT1) and type 2 (AT2) cells. Bipotent alveolar progenitor cells (BPCs), which give rise to both AT1 and AT2 cells, are disrupted in many lung diseases. Generating mature alveolar cells from human pluripotent stem cells (hPSCs) offers a promising strategy for alveolar epithelium regeneration but remains challenging. W...

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Literature Corpus work: 904884db-466b-5dda-9908-f4cbd8993eb0
DOI: 10.21203/rs.3.rs-7474344/v1

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