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Mapping sex differences in brain and cognition in relation to<i>APOE4</i>and amyloid burden: A longitudinal normative modelling study

2025-06-23

Abstract excerpt

Sex differences in Alzheimer’s disease (AD) risk and progression are increasingly recognized, with females exhibiting higher global prevalence rates. Yet it remains unclear how genetic and biomarker indicators of Alzheimer’s risk, such as the apolipoprotein E-ɛ4 ( APOE4 ) allele and amyloid burden, relate to sex differences in brain and cognitive health during the preclinical stage. Using established normative mod...

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Literature Corpus work
0145cf8e-4f52-5e96-8c03-28d846a0f527
DOI
10.1101/2025.06.22.25330074
Open publication

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Mapping sex differences in brain and cognition in relation to<i>APOE4</i>and amyloid burden: A longitudinal normative modelling studyDOI 10.1101/2025.06.22.25330074
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