Sex differences in the genetic predictors of Alzheimer's pathology.

doi:10.1093/brain/awz206

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Article

Sex differences in the genetic predictors of Alzheimer's pathology.

Brain : a journal of neurology - 1 Sept 2019

Dumitrescu Logan, Barnes Lisa L, Thambisetty Madhav, Beecham Gary, Kunkle Brian, Bush William S, Gifford Katherine A, Chibnik Lori B, Mukherjee Shubhabrata, De Jager Philip L, Kukull Walter, Crane Paul K, Resnick Susan M, Keene C Dirk, Montine Thomas J, Schellenberg Gerard D, Deming Yuetiva, Chao Michael J, Huentelman Matt, Martin Eden R, Hamilton-Nelson Kara, Shaw Leslie M, Trojanowski John Q, Peskind Elaine R, Cruchaga Carlos, Pericak-Vance Margaret A, Goate Alison M, Cox Nancy J, Haines Jonathan L, Zetterberg Henrik, Blennow Kaj, Larson Eric B, Johnson Sterling C, Albert Marilyn, Bennett David A, Schneider Julie A, Jefferson Angela L, Hohman Timothy J

Abstract excerpt

Autopsy measures of Alzheimer's disease neuropathology have been leveraged as endophenotypes in previous genome-wide association studies (GWAS). However, despite evidence of sex differences in Alzheimer's disease risk, sex-stratified models have not been incorporated into previous GWAS analyses. We looked for sex-specific genetic associations with Alzheimer's disease endophenotypes from six brain bank data...

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PMID: 31497858
DOI: 10.1093/brain/awz206
PMCID: PMC6736148

Genes

APOE

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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