Article

Plasticity of Epigenomic and Transcriptomic Aging Reveals Common Targets for Reprogramming by Environmental Exposures

2025-09-19

Abstract excerpt

<title>Abstract</title> <p>Environmental exposures during early life are increasingly recognized as key determinants of health and disease in adulthood (1) but how they durably shape disease risk across the lifecourse remains poorly understood. Here, we show early-life toxicants reprogram the epigenome and redirect age-associated transcriptional trajectories—polarizing cell-specific gene expression and predisposi...

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Literature Corpus work: 5d6fc8ee-e968-5a99-85a7-55a3e0d0063a
DOI: 10.21203/rs.3.rs-7368222/v1

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