Article

Single-cell transcriptomics reveals zone-specific alterations of liver sinusoidal endothelial cells in cirrhosis

2020-03-20

Abstract excerpt

Dysfunction of liver endothelial cells (ECs), particularly sinusoidal endothelial cells (LSECs), is permissive for the progression of liver fibrosis/cirrhosis and responsible for its clinical complications. Here, we have mapped the spatial distribution of heterogeneous liver ECs in normal versus cirrhotic mouse livers and identified zone-specific transcriptomic changes of LSECs associated with liver cirrhosis usin...

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Literature Corpus work: 6fe23e3c-7e6a-5a16-97ac-a1944f1ab34e
DOI: 10.1101/2020.03.18.997452

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