Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Single-Cell Transcriptome Analysis of Mouse Liver Cell-Specific Tropism and Transcriptional Dysregulation Following Intravenous Administration of AAVrh.10 Vectors

7 Mar 2020

Abstract excerpt

Capitalizing on liver tropism of adeno-associated viral (AAV) vectors, intravenous vector administration is commonly used to genetically modify hepatocytes, a strategy currently in clinical trials for a number of liver-based hereditary disorders. Although hepatocytes are known to exhibit extensive phenotypic heterogeneity influenced by liver zonation and dietary cycle, there is little data available for the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to CRISPR and Genetic Engineering
Share to Viral gastroenteritis research and epidemiology
Share to Virus-based gene therapy research

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 32143547
DOI: 10.1089/hum.2019.366

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Single-Cell Transcriptome Analysis of Mouse Liver Cell-Specific Tropism and Transcriptional Dysregulation Following Intravenous Administration of AAVrh.10 VectorsPMID 32143547Read ↗

Specificity and off-target effects of AAV8-TBG viral vectors for the manipulation of hepatocellular gene expression in miceSemantic proximity Read ↗

Genetic manipulation using hepatocyte-targeting adeno-associated viral vectors has minimal off-target effectsSemantic proximity Read ↗

Assessment of pre-clinical liver models based on their ability to predict the liver-tropism of AAV vectorsSemantic proximity Read ↗

Novel Transgenic Humanized Alpha-1 Antitrypsin Deficiency Mouse Model on Murine <i>SERPINA1</i> Null BackgroundSemantic proximity Read ↗

Assessment of Pre-Clinical Liver Models Based on Their Ability to Predict the Liver-Tropism of Adeno-Associated Virus VectorsSemantic proximity Read ↗

The Evolution of Gene Therapy in the Treatment of Metabolic Liver Diseases.Semantic proximity Read ↗

Impact of liver fibrosis on AAV-mediated gene transfer to mouse hepatocytesSemantic proximity Read ↗

A single-nucleus and spatial transcriptomic atlas of the COVID-19 liver reveals topological, functional, and regenerative organ disruption in patientsSemantic proximity Read ↗

A comprehensive molecular atlas of the cell types in the mouse liverSemantic proximity Read ↗

Liver directed adeno‐associated viral vectors to treat metabolic diseaseSemantic proximity Read ↗

Single transcript-level metabolic responsive landscape of human liver transcriptomeSemantic proximity Read ↗

Single-cell RNA transcriptome landscape of hepatocytes and non-parenchymal cells in healthy and NAFLD mouse liverSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.