Article

Kupffer cells dictate hepatic responses to the atherogenic dyslipidemic insult

2022-10-17

Abstract excerpt

Apolipoprotein-B (APOB) containing lipoproteins are causative for atherosclerotic cardiovascular disease. Whether the vasculature is the initial responding site or if atherogenic-dyslipidemia effects other organs simultaneously is unknown. We set out to discover how the liver responds to a dyslipidemic insult through the creation of inducible mouse models based on human familial hypercholesterolemia mutations and...

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Literature Corpus work: 0c0c30ed-dee1-5d76-a0cd-9f107794fa81
DOI: 10.1101/2022.10.13.512086

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