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Early-Life Environmental Exposures Reprogram Epigenomic Aging to Alter Gene Expression Trajectories

2025-04-22

Abstract excerpt

<h4>ABSTRACT</h4> To understand how early-life environmental exposures shape health and disease risk across the lifecourse, the TaRGET II Consortium exposed mice to diverse toxicants from pre-conception through weaning, and followed individual animals into adulthood, generating over 800 epigenomic and transcriptomic profiles. These profiles revealed that early-life exposures induced persistent epigenomic reprogra...

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Literature Corpus work
fe2b8c20-734b-5dc4-8115-158bc17c2263
DOI
10.1101/2025.04.21.649824
Open publication

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Early-Life Environmental Exposures Reprogram Epigenomic Aging to Alter Gene Expression TrajectoriesDOI 10.1101/2025.04.21.649824
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