Article

Autotaxin Inhibition Ameliorates HFpEF Phenotype By Reducing LPA-Mediated Systemic Inflammation And Cardiac Remodeling

2026-08-30

Abstract excerpt

<h4>Background: </h4> HFpEF accounts for roughly half of heart failure admissions and lacks disease-modifying therapy. Autotaxin (ENPP2) generates lysophosphatidic acid (LPA), a profibrotic and pro-inflammatory bioactive lipid. Whether circulating lysophospholipid metabolism is altered in HFpEF, and whether autotaxin inhibition modifies an established experimental HFpEF phenotype, is untested. <h4>Methods:</h4> Pl...

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Literature Corpus work: 011ca061-95ba-566a-b213-138b4db87ae5
DOI: 10.64898/2026.08.26.747366

Open publication

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