Defining tissue- and disease-associated macrophages using a transcriptome-based classification model

Abstract excerpt

Macrophages are heterogeneous multifunctional leukocytes which are regulated in a tissue-and disease-specific context. Many different studies have been published using in vitro macrophage models to study disease. Here, we aggregated public expression data to define consensus expression profiles for eight commonly-used in vitro macrophage models. Altogether, we observed well-known but also novel markers for diffe...

Topics

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• Atherosclerosis
• Dendritic Cells
• Macrophages
• Monocytes
• Plaque, Atherosclerotic
• Receptors, Immunologic
• RNA-Seq
• Single-Cell Analysis

Identifiers and source

Literature Corpus work

c0646688-edff-5553-b663-3a913f5a2adb

DOI

10.1101/532986