Article
IFN-γ Drives Human Monocyte Differentiation into Highly Proinflammatory Macrophages That Resemble a Phenotype Relevant to Psoriasis.
Journal of immunology (Baltimore, Md. : 1950) - 15 Jul 2021
Luque-Martin Rosario, Angell Davina C, Kalxdorf Mathias, Bernard Sharon, Thompson William, Eberl H Christian, Ashby Charlotte, Freudenberg Johannes, Sharp Catriona, Van den Bossche Jan, de Jonge Wouter J, Rioja Inmaculada, Prinjha Rab K, Neele Annette E, de Winther Menno P J, Mander Palwinder K
Abstract excerpt
As key cells of the immune system, macrophages coordinate the activation and regulation of the immune response. Macrophages present a complex phenotype that can vary from homeostatic, proinflammatory, and profibrotic to anti-inflammatory phenotypes. The factors that drive the differentiation from monocyte to macrophage largely define the resultant phenotype, as has been shown by the differences found in M-CSF-...
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