Article

Early IFNβ secretion determines variable downstream IL-12p70 responses upon TLR4 activation in health and disease

2020-12-22

Abstract excerpt

<h4>Summary</h4> The IL-12 family of cytokines comprises the only heterodimeric cytokines mediating diverse functional effects. We previously observed a bi-modal IL-12p70 response to LPS in healthy donors of the Milieu Interieur cohort. Herein, we demonstrate that IFNβ expression serves as an upstream determinant of variable IL-12p70 production. Integrative modelling of proteomic, genetic, epigenomic and cellular...

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Literature Corpus work: 73244c73-c410-5278-8ab8-7e028ef73733
DOI: 10.1101/2020.12.19.20248132

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