Article

Neuronal exosomes transport a miRNA/RISC cargo to preserve germline stem cell integrity during energy stress

2023-11-17

Abstract excerpt

During periods of nutrient scarcity, many animals undergo germline quiescence to preserve reproductive capacity, and neurons are often necessary for this adaptation. We show here that starvation causes the release of neuronal miRNA/Argonaute-loaded exosomes following AMPK-regulated trafficking changes within serotonergic neurons. This neuron-to-germ line communication is independent of classical serotonergic neuro...

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Identifiers and source

Literature Corpus work: 00d54539-8958-5562-bd96-6853e5fed409
DOI: 10.1101/2023.11.15.567290

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