Article

AMPK regulates germline stem cell integrity and quiescence through a <i>mir-1/tbc-7/rab-7</i> pathway in <i>C. elegans</i>

2021-09-24

Abstract excerpt

During periods of energetic stress, Caenorhabditis elegans can undergo a global quiescent stage known as “dauer”. During this stage, all germline stem cells undergo G2 cell cycle arrest through an AMPK-dependent mechanism. In animals that lack AMPK signalling, the germ cells fail to arrest, undergo uncontrolled proliferation and lose their reproductive capacity. These germline defects are accompanied by an altere...

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Identifiers and source

Literature Corpus work: 5170443a-cc4f-5010-9db8-325a5f9620cb
DOI: 10.1101/2021.09.22.461433

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