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Article

AMPK tunes reproductive gene expression and small RNA homeostasis to mediate timely germ cell development.

Nucleic acids research - 8 Jun 2026

Rashid Sabih, Braukmann Fabian, Miska Eric A, Roy Richard

Abstract excerpt

Developmental plasticity allows organisms to adapt to environmental stressors and improve fitness. Caenorhabditis elegans can enter an alternative larval stage, the dauer, marked by developmental quiescence and complete transcriptomic remodeling. The energy modulator AMPK is required for animals to passage through dauer while preserving germline quiescence. Without AMPK, dauer animals exhibit reproductive...

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Identifiers

PMID: 42258542
DOI: 10.1093/nar/gkag555
PMCID: PMC13291822

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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