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Alternative somatic and germline gene-regulatory strategies during starvation-induced developmental arrest

1 Oct 2022

Abstract excerpt

Nutrient availability governs growth and quiescence, and many animals arrest development when starved. Using C. elegans L1 arrest as a model, we show that gene expression changes deep into starvation. Surprisingly, relative expression of germline-enriched genes increases for days. We conditionally degrade the large subunit of RNA polymerase II using the auxin-inducible degron system and analyze absolute...

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PMID: 36223742
DOI: 10.1016/j.celrep.2022.111473

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