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Surviving Starvation: AMPK Protects Germ Cell Integrity by Targeting Multiple Epigenetic Effectors.

BioEssays : news and reviews in molecular, cellular and developmental biology - 1 Mar 2018

Demoinet Emilie, Roy Richard

Abstract excerpt

Acute starvation can have long-term consequences that are mediated through epigenetic change. Some of these changes are affected by the activity of AMP-activated protein kinase (AMPK), a master regulator of cellular energy homeostasis. In Caenorhabditis elegans, the absence of AMPK during a period of starvation in an early larval stage results in developmental defects following their recovery on food, while many...

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PMID: 29430674
DOI: 10.1002/bies.201700095

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