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Article

Transcriptional Control of Mitochondrial Biogenesis and Function

13 Feb 2009

Abstract excerpt

Mitochondria play central roles in energy homeostasis, metabolism, signaling, and apoptosis. Accordingly, the abundance, morphology, and functional properties of mitochondria are finely tuned to meet cell-specific energetic, metabolic, and signaling demands. This tuning is largely achieved at the level of transcriptional regulation. A highly interconnected network of transcription factors regulates a broad set of...

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PMID: 19575678
DOI: 10.1146/annurev.physiol.010908.163119

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