Article

Single-cell imaging reveals unexpected heterogeneity of TERT expression across cancer cell lines

2019-04-25

Abstract excerpt

Telomerase is pathologically reactivated in most human cancers, where it maintains chromosomal telomeres and allows immortalization. Because telomerase reverse transcriptase (TERT) is usually the limiting component for telomerase activation, numerous studies have measured TERT mRNA levels in populations of cells or in tissues. However, little is known about TERT expression at the single-cell and single-molecule le...

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Literature Corpus work: 00d052d7-22b1-5ce1-b279-bdc95dde6b7d
DOI: 10.1101/618769

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