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Article

A novel two-step genome editing strategy with CRISPR-Cas9 provides new insights into telomerase action and TERT gene expression.

Genome biology - 10 Nov 2015

Xi Linghe, Schmidt Jens C, Zaug Arthur J, Ascarrunz Dante R, Cech Thomas R

Abstract excerpt

BACKGROUND: To facilitate indefinite proliferation, stem cells and most cancer cells require the activity of telomerase, which counteracts the successive shortening of telomeres caused by incomplete DNA replication at the very end of each chromosome. Human telomerase activity is often determined by the expression level of telomerase reverse transcriptase (TERT), the catalytic subunit of the ribonucleoprotein...

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Identifiers

PMID: 26553065
DOI: 10.1186/s13059-015-0791-1
PMCID: PMC4640169

Genes

TERT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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