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Article

ALCAT1 controls mitochondrial etiology of fatty liver diseases, linking defective mitophagy to steatosis

9 Sept 2014

Abstract excerpt

UNLABELLED: Defective autophagy is implicated in the pathogenesis of nonalcoholic fatty liver diseases (NAFLD) through poorly defined mechanisms. Cardiolipin is a mitochondrial phospholipid required for bioenergetics and mitophagy from yeast to mammals. Here we investigated a role for ALCAT1 in the development of NAFLD. ALCAT1 is a lysocardiolipin acyltransferase that catalyzes pathological cardiolipin remodeling...

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Share to Autophagy in Disease and Therapy
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PMID: 25203315
DOI: 10.1002/hep.27420

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