Article

Leveraging gene co-regulation to identify gene sets enriched for disease heritability

2021-07-26

Abstract excerpt

Identifying gene sets that are associated to disease can provide valuable biological knowledge, but a fundamental challenge of gene set analyses of GWAS data is linking disease-associated SNPs to genes. Transcriptome-wide association studies (TWAS) can be used to detect associations between the genetically predicted expression of a gene and disease risk, thus implicating candidate disease genes. However, causal di...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 51b3bab2-cd7a-5429-86ac-a08d95b3b569
DOI: 10.1101/2021.07.22.453442

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Leveraging gene co-regulation to identify gene sets enriched for disease heritabilityDOI 10.1101/2021.07.22.453442Read

Leveraging gene co-regulation to identify gene sets enriched for disease heritability.Semantic proximity Read

Modeling tissue co-regulation to estimate tissue-specific contributions to diseaseSemantic proximity Read

Co-expression-wide association studies link genetically regulated interactions with complex traitsSemantic proximity Read

Estimating the proportion of disease heritability mediated by gene expression levelsSemantic proximity Read

Modeling tissue co-regulation estimates tissue-specific contributions to disease.Semantic proximity Read

Leveraging Gene Co-expression Patterns to Infer Trait-Relevant Tissues in Genome-wide Association StudiesSemantic proximity Read

Gene co-expression analysis for functional classification and gene-disease predictions.Semantic proximity Read

Identification of genetic variants that impact gene co-expression relationships using large-scale single-cell dataSemantic proximity Read

Identification of genetic variants that impact gene co-expression relationships using large-scale single-cell data.Semantic proximity Read

A powerful framework for differential co-expression analysis of general risk factorsSemantic proximity Read

The molecular basis, genetic control and pleiotropic effects of local gene co-expressionSemantic proximity Read

CATaN maps gene regulatory programs that shape genetic risk across complex diseasesSemantic proximity Read