Article

Modeling tissue co-regulation to estimate tissue-specific contributions to disease

2022-08-26

Abstract excerpt

Integrative analyses of genome-wide association studies (GWAS) and gene expression data across diverse tissues and cell types have enabled the identification of putative disease-critical tissues. However, co-regulation of genetic effects on gene expression across tissues makes it difficult to distinguish biologically causal tissues from tagging tissues. While previous work emphasized the potential of accounting fo...

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Literature Corpus work: 57f76e82-d3d5-53a6-b09a-dcdba746bdaa
DOI: 10.1101/2022.08.25.505354

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