Back to search

Article

ABCA7 deficiency exacerbates glutamate excitotoxicity in Alzheimer’s disease mice – a new pharmacological target for Glu-related neurotoxicity

2025-07-31

Abstract excerpt

Increasing attention has been directed towards the perturbation of glutamate (Glu) and γ-aminobutyric acid (GABA) homeostasis during the pathogenesis of Alzheimer’s disease (AD). The prevailing disequilibrium, stemming from hyperactivation of the glutamatergic system, culminates in progressive neuronal impairment and cognitive deterioration. This study aimed to elucidate the contributory role of the ATP-binding ca...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
0052d8b5-cafa-5ab8-8b21-59cb54fc2fb0
DOI
10.1101/2025.07.25.666774
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
ABCA7 deficiency exacerbates glutamate excitotoxicity in Alzheimer’s disease mice – a new pharmacological target for Glu-related neurotoxicityDOI 10.1101/2025.07.25.666774
ABCA7 Deficiency Accelerates Amyloid-β Generation and Alzheimer's Neuronal Pathology.Semantic proximity
ABCA7 and Pathogenic Pathways of Alzheimer’s DiseaseSemantic proximity
The role of ATP-binding cassette subfamily A in the etiology of Alzheimer’s diseaseSemantic proximity
The ABC's of Alzheimer risk gene ABCA7.Semantic proximity
Disrupted Lipid Homeostasis as a Pathogenic Mechanism in <i>ABCA7</i> -Associated Alzheimer’s Disease RiskSemantic proximity
ABCA7-Associated Clinical Features and Molecular Mechanisms in Alzheimer’s DiseaseSemantic proximity
Role of ABCA7 in Human Health and in Alzheimer's Disease.Semantic proximity
ABCA7 in Alzheimer's Disease.Semantic proximity
ABC Transporters Are Key Players in Alzheimer’s DiseaseSemantic proximity
Potential Astrocytic Receptors and Transporters in the Pathogenesis of Alzheimer’s DiseaseSemantic proximity
The role of ABCA7 in Alzheimer’s disease: evidence from genomics, transcriptomics and methylomicsSemantic proximity
The role of the ATP-Binding Cassette A1 (ABCA1) in neurological disorders: a mechanistic reviewSemantic proximity
Select a neighboring publication to make it the new centre.