Article
ABCA7 Deficiency Accelerates Amyloid-β Generation and Alzheimer's Neuronal Pathology.
The Journal of neuroscience : the official journal of the Society for Neuroscience - 30 Mar 2016
Sakae Nobutaka, Liu Chia-Chen, Shinohara Mitsuru, Frisch-Daiello Jessica, Ma Li, Yamazaki Yu, Tachibana Masaya, Younkin Linda, Kurti Aishe, Carrasquillo Minerva M, Zou Fanggeng, Sevlever Daniel, Bisceglio Gina, Gan Ming, Fol Romain, Knight Patrick, Wang Miao, Han Xianlin, Fryer John D, Fitzgerald Michael L, Ohyagi Yasumasa, Younkin Steven G, Bu Guojun, Kanekiyo Takahisa
Abstract excerpt
In Alzheimer's disease (AD), the accumulation and deposition of amyloid-β (Aβ) peptides in the brain is a central event. Aβ is cleaved from amyloid precursor protein (APP) by β-secretase and γ-secretase mainly in neurons. Although mutations inAPP,PS1, orPS2cause early-onset familial AD,ABCA7encoding ATP-binding cassette transporter A7 is one of the susceptibility genes for late-onset AD (LOAD), in which...
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