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Article

Role of ABCA7 in Human Health and in Alzheimer's Disease.

International journal of molecular sciences - 27 Apr 2021

Dib Shiraz, Pahnke Jens, Gosselet Fabien

Abstract excerpt

Several studies, including genome wide association studies (GWAS), have strongly suggested a central role for the ATP-binding cassette transporter subfamily A member 7 (ABCA7) in Alzheimer's disease (AD). This ABC transporter is now considered as an important genetic determinant for late onset Alzheimer disease (LOAD) by regulating several molecular processes such as cholesterol metabolism and amyloid processing...

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Identifiers

PMID: 33925691
DOI: 10.3390/ijms22094603
PMCID: PMC8124837

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