Article

Dynamic basis for dA-dGTP and dA-d8OGTP misincorporation via Hoogsteen base pairs

2022-09-12

Abstract excerpt

<title>Abstract</title> <p>Replicative errors contribute to the genetic diversity needed for evolution but in high frequency can lead to genomic instability. The mechanisms determining the frequency of DNA copying errors are not fully understood. Here, we show DNA dynamics determines the frequency of misincorporating the A-G mismatch and altered dynamics explains the high frequency of 8-oxoguanine (8OG) A-8OG mis...

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Literature Corpus work: 003e97be-9a8d-500c-92e0-15ba0939bd6c
DOI: 10.21203/rs.3.rs-1979339/v1

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