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Article

Visualizing transient Watson-Crick-like mispairs in DNA and RNA duplexes.

Nature - 19 Mar 2015

Kimsey Isaac J, Petzold Katja, Sathyamoorthy Bharathwaj, Stein Zachary W, Al-Hashimi Hashim M

Abstract excerpt

Rare tautomeric and anionic nucleobases are believed to have fundamental biological roles, but their prevalence and functional importance has remained elusive because they exist transiently, in low abundance, and involve subtle movements of protons that are difficult to visualize. Using NMR relaxation dispersion, we show here that wobble dG•dT and rG•rU mispairs in DNA and RNA duplexes exist in dynamic...

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Identifiers

PMID: 25762137
DOI: 10.1038/nature14227
PMCID: PMC4547696

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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