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Inosine-Induced Base Pairing Diversity during Reverse Transcription

22 Jan 2024

Abstract excerpt

A-to-I editing catalyzed by adenosine deaminase acting on RNAs impacts numerous physiological and biochemical processes that are essential for cellular functions and is a big contributor to the infectivity of certain RNA viruses. The outcome of this deamination leads to changes in the eukaryotic transcriptome functionally resembling A-G transitions since inosine preferentially pairs with cytosine. Moreover,...

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PMID: 38252964
DOI: 10.1021/acschembio.3c00555

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