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Article

Sequence context effect on strand slippage in natural DNA primer-templates.

The journal of physical chemistry. B - 16 Feb 2012

Chi Lai Man, Lam Sik Lok

Abstract excerpt

Strand slippage has been found to occur in primer-templates containing a templating thymine, cytosine, and guanine, leading to the formation of misaligned structures with a single-nucleotide bulge. If remained in the active site of low-fidelity polymerases during DNA replication, these misaligned structures can ultimately bring about deletion mutations. In this study, we performed NMR investigations on...

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PMID: 22304666
DOI: 10.1021/jp211666k

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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