Article

Disulfide constrained Fabs overcome target size limitation for high-resolution single-particle cryo-EM

2024-05-13

Abstract excerpt

<h4>ABSTRACT</h4> High-resolution structures of proteins are critical to understanding molecular mechanisms of biological processes and in the discovery of therapeutic molecules. Cryo-EM has revolutionized structure determination of large proteins and their complexes 1 , but a vast majority of proteins that underlie human diseases are small (< 50 kDa) and usually beyond its reach due to low signal-to-noise image...

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Literature Corpus work: 003e53f1-d5c8-5841-b469-1dbd84b3780e
DOI: 10.1101/2024.05.10.593593

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