Article

Cryo-electron microscopy reveals a single domain antibody with a unique binding epitope on fibroblast activation protein alpha

2024-10-20

Abstract excerpt

Fibroblast activation protein alpha (FAP) is a serine protease that is expressed at basal levels in benign tissues but is overexpressed in a variety of pathologies, including cancer. Despite this unique expression profile, designing effective diagnostic and therapeutic agents that effectively target this biomarker remain elusive. Here we report the structural characterization of the interaction between a novel sin...

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Literature Corpus work: 0901c61a-76ba-5563-984e-1f18d0363560
DOI: 10.1101/2024.10.18.619146

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Cryo-electron microscopy reveals a single domain antibody with a unique binding epitope on fibroblast activation protein alphaDOI 10.1101/2024.10.18.619146Read

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