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Article

Functional Divergence in the Affinity and Stability of Non-Canonical Cysteines and Non-Canonical Disulfide Bonds: Insights from a VHH and VNAR Study.

International journal of molecular sciences - 11 Sept 2024

Xu Mingce, Zhao Zheng, Deng Penghui, Sun Mengsi, Chiu Cookson K C, Wu Yujie, Wang Hao, Bi Yunchen

Abstract excerpt

Single-domain antibodies, including variable domains of the heavy chains of heavy chain-only antibodies (VHHs) from camelids and variable domains of immunoglobulin new antigen receptors (VNARs) from cartilaginous fish, show the therapeutic potential of targeting antigens in a cytosol reducing environment. A large proportion of single-domain antibodies contain non-canonical cysteines and corresponding...

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Identifiers

PMID: 39337289
DOI: 10.3390/ijms25189801
PMCID: PMC11432006

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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