Article

Comparative Profiling of TCR Repertoires in Extranodal NK/T-Cell Lymphoma and Healthy Individuals Highlights Unique Clonal Expansions and Potential Diagnostic Biomarkers

2025-11-18

Abstract excerpt

<title>Abstract</title> <p>T-cell receptor (TCR) repertoire profiling is crucial for elucidating immune responses in Extranodal NK/T-cell lymphoma (ENKTL). In this study, TCR sequencing of paraffin-embedded samples was performed using MiXCR with stringent quality control (85–95% aligned reads, 60–80% clonotype reads, < 5% low-quality reads). ENKTL patients exhibited marked clonal expansion, with the top clone fre...

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Literature Corpus work: a9f0544d-6019-50e8-a0c7-d41882848571
DOI: 10.21203/rs.3.rs-7756995/v1

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