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Article

Single-cell RNA sequencing identifies celltype-specific cis-eQTLs and co-expression QTLs.

Nature genetics - 1 Apr 2018

van der Wijst Monique G P, Brugge Harm, de Vries Dylan H, Deelen Patrick, Swertz Morris A, Franke Lude

Abstract excerpt

Genome-wide association studies have identified thousands of genetic variants that are associated with disease 1 . Most of these variants have small effect sizes, but their downstream expression effects, so-called expression quantitative trait loci (eQTLs), are often large 2 and celltype-specific3-5. To identify these celltype-specific eQTLs using an unbiased approach, we used single-cell RNA sequencing to...

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Identifiers

PMID: 29610479
DOI: 10.1038/s41588-018-0089-9
PMCID: PMC5905669

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