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Reversion of a RND transporter pseudogene uncovers latent stress resistance in <i>Brucella ovis</i>

2025-05-10

Abstract excerpt

<h4>ABSTRACT</h4> Small-molecule screens can advance therapeutic discovery while yielding new insights into pathogen biology. Through a luminescence-based screen, we identified clinically approved dihydropyridines that reduced the fitness of the intracellular pathogen Brucella ovis within mammalian phagocytes. Given the established role of dihydropyridines as inhibitors of mammalian L-type calcium channels and o...

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Literature Corpus work
002635bc-0d87-50f4-b950-6ad5dbf032df
DOI
10.1101/2025.05.10.653276
Open publication

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Reversion of a RND transporter pseudogene uncovers latent stress resistance in <i>Brucella ovis</i>DOI 10.1101/2025.05.10.653276
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